Splice is a 2009 Canadian/French science fiction horror film directed by Vincenzo Natali and starring Adrien Brody and Sarah Polley. The story concerns experiments in genetic engineering being done by a young scientist couple who attempt to introduce human DNA into their work of splicing animal genes.
Genetic engineers Clive Nicoli (Adrien Brody) and Elsa Kast (Sarah Polley) hope to achieve fame by successfully splicing together the DNA of different animals to create new hybrid animals for medical use. They have just created the second in a pair of identical hybrids; the new male specimen, Fred, is intended as a mate for the original specimen, a female called Ginger.
After their success, Clive and Elsa want to use human DNA to create a hybrid that could revolutionize science and medicine, but are forbidden by the pharmaceutical company that funds their research, N.E.R.D. (Nucleic Exchange Research and Development), instead mandating that their department be re-organized to focus on finding and extracting certain proteins from the creatures they have already created. Secretly, Clive and Elsa conduct their own experiments, blending human DNA with that of other animals.
Although they initially decide not to bring the hybrid to full term, Elsa pushes the issue and persuades Clive to go along with it, in continued secrecy. The hybrid appears deformed and aggressive when it stings Elsa several times after "birth" with a retractable stinger in its tail. Clive and Elsa believe they have killed the hybrid only to find out that within the body was the true hybrid. After anesthetizing and examining the creature, they discover that she is aging at an accelerated rate. Clive is still adamant that the creature should be killed, but Elsa convinces him that it is too late, and points out that, since the hybrid is slowly dying anyway, they should take advantage of this unique opportunity to observe its complete life cycle.
Elsa eventually names the creature Dren (“nerd” backwards) because Elsa refuses to let Clive refer to her as a "specimen". Elsa immediately forms a motherly bond with Dren, as Dren grows and learns at an accelerated rate. As their lab becomes more and more crowded, and after Dren attacks Clive's brother (a fellow lab technician), they move Dren to Elsa's late mother's farm.
Due to Dren's demands on Clive and Elsa's time, they begin to neglect their work, failing to read the logs kept by the other lab technicians on the progress of their original animal hybrids, Fred and Ginger. At the highly publicized "unveiling" of the two specimens, instead of mating, as expected, Fred and Ginger violently kill each other, creating a public relations disaster for the NERD company. It is subsequently discovered that Ginger, the female hybrid, has spontaneously changed to a male, but Elsa and Clive had failed to notice because they have been so wrapped up in caring for Dren.
As Dren grows into adolescence, she becomes moody and petulant. She becomes bored locked up in the barn, and wants to go outside, but Elsa and Clive refuse, as letting Dren outside could expose her to other people. Eventually, Dren lashes out, killing a pet cat out of spite and then assaulting Elsa. Elsa reacts by reverting back to the role of scientist. She ties Dren up, refuses to speak to her (referring to her only as "the specimen" again), and removing the stinger from her tail. She then uses the living tissue from the tail to finally isolate and synthesize the protein they had been searching for.
Soon after, Dren jumps naked on Clive, who initially refuses her sexual overtures. As Clive looks at Dren, however, he suddenly realizes that the human DNA used to make her was not from a "Jane Doe," as Elsa had told him, but from Elsa herself. Clive and Dren end up having sex, but are interrupted by Elsa. Clive follows Elsa back to their apartment and they have a heated argument, in which Clive confronts her about having used her own DNA to create Dren. He accuses Elsa of never wanting a normal child because she was afraid of losing control, which was why she had insisted on creating a creature in the context of a scientific experiment, where control could be assured. He says that the line between right and wrong has become blurred. The two finally decide to terminate the experiment, and presumably end Dren's life.
But when they return to the farm, they discover that Dren is dying. Some hours later, they bury her behind the barn. Minutes afterwards, their boss from the lab arrives with Clive's younger brother Gavin. Gavin is aware of Dren's existence and has confirmed Barlow's suspicions that some sort of human hybrid has been created (due to the human DNA he found present in the new protein Elsa synthesized). Just as Elsa is telling him that Dren is already dead, Dren attacks them, killing t
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