Resident Evil is a British-German 2002 horror film written and directed by Paul W.S. Anderson. The film stars Milla Jovovich, Michelle Rodriguez, Eric Mabius, and James Purefoy. It is based on the same titled series of survival horror games developed by Capcom. Borrowing elements from the video games Resident Evil and Resident Evil 2, the film follows amnesiac heroine Alice and a band of Umbrella Corporation commandos as they attempt to contain the outbreak of the T-Virus at a secret underground facility.
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Inside the Hive, a top-secret genetic research facility owned by the Umbrella Corporation located beneath Raccoon City, a thief throws a vial of the T-Virus into a lab causing it to escape into the air vents. The vial breaks and the facility's artificial intelligence, the Red Queen, detects possible infection. It seals the Hive, trapping and killing everyone inside.
Alice (Milla Jovovich) awakens in an empty mansion with amnesia. She and a police officer, Matt (Eric Mabius), are seized by a group of commandos and taken to an underground train station that leads to The Hive. The group discovers Spence (James Purefoy), also suffering from amnesia. The head of the commandos, "One" (Colin Salmon), explains that everyone in the group except Matt is an employee of the Umbrella Corporation. The Red Queen released a nerve gas in the mansion that caused their amnesia. The group boards the train and travels to The Hive.
They find their way to The Queen's chamber, but it is protected by a laser defense system. Four of the commandos are killed including One. The only commandos left alive are Rain (Michelle Rodriguez), Kaplan (Martin Crewes), and J.D. They set up an EMP device to disable The Queen. The AI manifests itself as the holographic of a young girl and pleads with them not to disable it, claiming that if they do then bad things will happen. The Queen's warnings are ignored; the system is disabled and the power fails, causing all of the doors to open, releasing the zombified staff into The Hive. During a running battle with the zombies, Rain becomes infected after being bitten and J.D is killed. Alice and Spence begin to regain their memories, but Matt and Alice are separated from Kaplan, Rain and Spence. Matt looks for information about his sister while Alice encounters several experimental dogs and surprises herself when she uses martial arts to defend herself.
Matt finds his sister, Lisa (Heike Makatsch), is already a zombie. As she attacks him Alice arrives in time to save him. Matt explains that he and Lisa attempted to smuggle out a sample of the blue vial, the T-Virus, to take down Umbrella. Matt believes that Lisa's contact is the one to blame for supposedly betraying her. Alice remembers she was Lisa's contact, but does not tell Matt. After being chased, the survivors reunite at The Queen's chamber. Alice turns The Queen back on in order to find an exit; the Red Queen agrees to help them. As they try escaping through the maintenance tunnels, they are ambushed by zombies. Kaplan is separated from the rest as pipes collapse while the group is crossing over them. Alice remembers that an anti-virus exists, a vial of green liquid.
At the lab they find the vials containing the T-Virus and anti-virus are gone. Spence regains his memory and realizes he was the person who stole and released the virus. He stashed the vials on the train. Spence gets bitten then traps the survivors in the lab then heads toward the train. Before he can inject himself with the anti-virus he is killed by a mutated creature called a Licker. The Red Queen offers to spare Alice and Matt if they kill Rain, who has been infected for too long for the anti-virus to work. As the Licker attempts to bash through the lab window to get to them, Rain tells Alice to chop off her head. After Alice smashes the monitor which the Red Queen was using to talk to them, a power-outage occurs
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