Osmosis Jones is a 2001 live-action/animated Comedy film directed by Tom Sito and Piet Kroon for the animated segments and the Farrelly brothers for the live-action segments. Unusual in this genre, the live-action characters never meet the animated characters.
Francis "Frank" Detorre (Bill Murray) is a widowed slovenly zookeeper at the Sucat Memorial Zoo in Rhode Island. Much to the frustration of his young daughter, Shane (Elena Franklin), he eats compulsively unhealthily and has no regard for germs or disease. While trying to eat a hard-boiled egg with mayonnaise and salt, it is stolen from him by a chimpanzee. He gets it back, but not before it falls into the filth of the chimp's habitat. When Shane is disgusted by him about to eat it he uses the "ten second rule" as a justification for the unsanitary act.
Inside Frank's body, the story unfolds. Protagonist Osmosis "Ozzy" Jones (Chris Rock), an agent of the FrankPD, is a hot-tempered, adventure-seeking leukocyte. He is a rebel cop, frequently disobeying what an authority tells him to do for what he thinks is right. He grew up poor on the "South Side" of Frank and is often mocked by his fellow cops due to his rebellious nature. At the beginning of the story, he has been relocated to the mouth to fight against germs entering the body via ingestion following an incident during which he induced Frank to vomit all over Shane's teacher, which was considered a false alarm because he had been the only one to suspect an incoming pathological threat. After several newcomer germs, believed to be gingivitis, hijack a "squad car" in the mouth, Jones and his senior partner, who is piloting their helicopter, are pulled into the lungs by a massive yawn while in pursuit. Even after the germs evade capture and pass into "Immunity's" jurisdiction, Jones disobeys direct orders and continues the pursuit on foot. The criminals escape and Jones accidentally triggers a major cramp in Frank's leg.
Meanwhile, Mayor Phlegmming is preparing for re-election, campaigning with the promise of more junk food (much to the joy of the citizens in the Love Handle District). His reckless policies are largely responsible for Frank's deteriorating health; but his re-election hopes are complicated by the arrival of Thrax, a deadly virus that came with the hard-boiled egg. In an attempt to cover up the severity of the situation, Phlegmming "tells" Frank to take a cold-suppressant pill. The pill, nicknamed Drix (short for Drixobenzometapetramine and his brand name Drixenol), arrives in the body and covers Frank's infected throat with a disinfectant to soothe the irritation. Osmosis Jones is assigned as Drix's partner, much to his chagrin. Eventually, they reveal Thrax's plot to masquerade as the common cold while at the same time plotting to overheat Frank's body, killing him from the inside. Thrax is motivated by a desire to become the nastiest new virus, attempting to kill each new victim faster than the previous. His plan for Frank is
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